What is sophora flavescens?
Though literally translated as bitter ginseng in English, Ku Shen
has nothing to do with ginseng at all. Actually it is another
completely different Chinese herb, which is better known as sophora
flavescens or sophora root in common name and Radix Sophorae
Flavescentis in Latin name. Likewise, it has different medicinal
properties and health benefits. This herb was first mentioned in
“Shen Nong’s Herbal Classic” and viewed as one of the medium-grade
drugs. That means it may be poisonous but can heal sickness and
tonify deficiency when used appropriately. As a matter of fact, it
is a good medicine for clearing heat, removing dampness, hair
growth, and killing insects, which makes it a really popular option
in the treatment of skin diseases and gynecological diseases.
The plant Sophora Flavescens is a Traditional Chinese Medicine that has been used for anti-tumor, viral hepatitis, enteritis,
viral myocarditis, arrhythmia, and skin diseases. It is sometimes referred to as Kushen or Ku Shen, and within the context of Traditional Chinese Medicine is is
known to have 'cooling' and antiphlogistic (anti-inflammatory)
Sophora flavescens Ait. (Leguminosae) has been proposed as a new
whitening agent for cosmetics, because it has a strong ability to
inhibit tyrosinase, a key enzyme in the formation of melanin.
Matrine is an alkaloid found in plants of the Sophora familiy. Matrine
depresses both glutamate-induced responses and neurally evoked
excitatory junctional potentials. This compound acts is also a
selective KOR (κ-opioid receptor) agonist.
Oxymatrine (matrine oxide, matrine N-oxide, matrine 1-oxide) is one of many quinolizidine alkaloid compounds extracted from the root of Sophora flavescens, a Chinese herb. It is very similar in structure to matrine, which has one less oxygen atom. Oxymatrine has a variety of
effects in vitro and in animal models, including protection against apoptosis, tumor and fibrotic tissue
development, and inflammation. Furthermore, oxymatrine has been shown to decrease cardiac ischemia(decreased blood perfusion), myocardial injury, arrhythmias(irregular heartbeats), and improve heart failure by increasing cardiac function.
|Product Name||Sophora Flavescens Extract|
Fluid Extract of Sophora japonica root and Oxymatrine injection in
rabit experiment proved good Diuresis Function,salt ejectment
content increase before increase of emiction.
Fluid Extract of Sophora japonica root in high concentration(1:100)
show good inhibiting ability to Mycobacterium tubereulosis. Fluid
Extract of Sophora japonica root in 8% concentration show
inhibiting ability to skin epiphyte.
3.Other Function of:
Oxymatrine injection to rabitt experiment prove central nerve
anesthesia synoms,togethor with spasm,breath stop and
die.Oxymatrine injection to frog experiment prove excitement
first,then palsy,breath turn low and irregular,spasm finally and
stop breath to death; and the cause of spasm perhaps origin from
reflect of spinal cord. the minimal death dosage to rabitt is about
4.Oxymatrine as best medicine and inhibitor of HBV(Hepatitis B
Virus) and inhibitor of HCV(Hepatitis C Virus)
Oxymatrine show powerful inhibiting bio activity to Hepatitis B
Virus(HBV) in animal experiment,also good function as inhibitor of
Hepatitis B Virus(Hepatitis B Virus inhibitor, HBV inhibitor).
A clinical case:Compare experiment of effect between Oxymatrine
injection and a-IFN injection to 64 patient of Hepatitis B Virus, 3
month cure with Oxymatrine(Dosage:600mg/one time/one day for 45
days;then 400mg/one time/one day for 45days),normal synoms of HBV
such as tired and no power,paunch bulge disappear rate about 90%
less or more, liver swell decreased and increased white blood cell
and blood platelet.Also good for liver function,recover rate of ALT
and recover rate of SB reach to 81.6% and 69.9%; Negative Change
Rate of HBeAg and HBV DNA show 444% and 45.3%, but the same index
by a-IFN injection only show 46.0% and 48.0%,no large
difference.Result metioned above show that Oxymatrine injection is
better to treat with Hepatitis B Virus(HBV).
Clinical Study from china show that: Oxymatrine injection once
daily,600mg muscle injection once for 39 HBV patient for 12
weeks,Negative Change Rate of HBeAg and HBV DN A result 44.4% and
50.0%, after ALT and AST treatment,function of liver improved
largely,total effectiveness amount to 70.0%,and this show the
Oxymatrine efffective for inhibiting HBV, at the same time, safety
enough and no any harm.
Another Case:Clinical Report Shows,Oxymatrine injection treatment
for 42 patient of HBV,result show the major index of recover rate
94.4% to 100%. swell of liver and spleen reduced by rate of 30.05
and 30.3%, increase white blood cell and blood platelet. Oxymatrine
recover rate to ALT,AST,SB result as 71.4%,61.9% and 100%; Negative
Change Rate of HBeAg and HBV DNA show 50% and 30.8%, show clear
difference to compare patient team.
Many Clinical Studies and report show that Oxymatrine injection and
other Oxymatrine remedy all good for HBV patient and improve liver
function,increase Negative Change Rate of HBeAg and HBV DNA, and
effective for long time since injection stopped.
Oxymatrine not only show function of inhibiting HBV, but also act
as inhibitor of HCV.
Clinical studies show that:Oxymatrine daily,600mg muscle injection
once for 17 patients of HCV,Negative Change of serum HBV DN A case
8, and rate 47.1%. but the compare team only case 1 and rate 5.6%.
differences between two teams, and Serum ALT Recover Rate of
Oxymatrine team higher than compare team later of the first month
and the second month,this result show that Oxymatrine have good
ability to inhibiting reproduce of HCV,and Oxymatrine have good
chances to be good inhibitor of HCV.
Mechanism of Oxymatrine as inhibitor of HBV and HCV:
(1).Oxymatrine could induce something in cell(as IFN) form,and this
could prompt Gene of HBV and HCV de-composition.
(2).Oxymatrine share similar structure as purine,and it's
inhibiting ability to HBV and HCV need more deep research.
6.Oxymatrine Against Liver Fibrosis:
Oxymatrine could act Against Liver Fibrosis
Clinical Report from china show that:Experiment Model of rat liver
damage by CCL4 and result liver fibrosis, cure with Oxymatrine,
test level of ALT,IV-C,HA,TNF-|A,and liver tissues,calculate by
computer,result show Oxymatrine result better than comparing team.
and this mean Oxymatrine could inhibiting fiber produce cell III
7.Oxymatrine adjust immune system.
Oxymatrine play as a kind of double-way adjustor for immune system,
low concentration level could stimulate lymphopoiesis,high
concentration of Oxymatrine inhibit lymphopoiesis,and inhibiting
function is major.
Clinical Study show Oxymatrine appear could be better inhibitor of
lung cancer, inhibitor of inner cell multiplication ,and Oxymatrine
could act as medicine to treat tumor cell shift.